Chromium Picolinate May Reduce Inflammation In Diabetic Kidney Disease (Nephropathy)
Chromium Supplement Linked to Decreased Protein in the Urine
Taking chromium picolinate may help lessen inflammation associated with diabetic nephropathy (kidney disease), say researchers at the Medical College of Georgia in Augusta. In a study comparing diabetic laboratory subjects treated with chromium picolinate with those that received placebo, the researchers found that those who received the supplement had lower levels of albuminuria (protein in the urine), an indication of kidney disease.
The researchers compared three groups of laboratory subjects, one lean, healthy group and two groups genetically engineered to be obese and have diabetes. When the subjects were 6 weeks old, the researchers separated them according to treatment plan. The healthy subjects and one group of diabetic subjects, the untreated diabetic group, were fed a regular diet. The remaining group, the treated diabetic group, were fed a diet enriched with chromium picolinate.
Over the course of 6 months, the researchers measured glycemic control and albuminuria in all three groups. The untreated diabetic subjects excreted nearly 10 times more albumin than the db/m subjects, which was to be expected. However, the treated diabetic subjects, who were fed the diet with chromium picolinate, excreted about half as much albumin compared to their untreated diabetic counterparts.
At the end of 6 months, the researchers studied tissue samples from the subjects’ kidneys. They found that the untreated diabetic subjects had marked immunostaining for interleukin 6 (IL-6) and interleukin 17 (IL-17), two cytokines associated with inflammation. These subjects also had moderate immuno-staining for indolamine 2,3-dioxygenase (IDO), an immunoregulatory enzyme that modulates the production of IL-6 and IL-17. However, the treated diabetic subjects had intense immunostaining for IDO but reduced IL-6 and IL-17 compared to the untreated diabetic group. The implication is that the chromium picolinate may have reduced inflammation in the treated diabetic group by affecting IDO, IL-6, and IL-7.
The researche team from the Medical College of Georgia Department of Oral Biology carefully noted that the results are preliminary and that further studies are necessary to tease out the effects of chromium picolinate. He is particularly interested in the relationship between IDO and chromium picolinate because IDO is involved in the metabolism of tryptophan, an amino acid, and one of the by-products of that metabolism is picolinic acid.
“This clearly raises an important question for us as to whether our observations are related to the provision of picolinic acid from the chromium picolinate or whether the formulation [chromium picolinate], in and of itself, is mediating the effects.” the researchers concluded.
The study was discussed at the 2010 American Physiological Society conference, Inflammation, Immunity, and Cardiovascular Disease, in Westminster Colorado.
Story Source: American Physiological Society (2010, September 22). Chromium picolinate may lessen inflammation in diabetic nephropathy;
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Dr. Riggin is FitFM - Family Wellness , is the Founder and Director of Healing Touch Oriental Medicine. As an inspiring health educator, in-demand speaker and doctor of acupuncture and Oriental Medicine, Dr. Mary has helped thousands of people completely turn their health around.
Dr. Mary co-hosts and produces the wildly popular radio show "Food is the First Medicine" and her presentations and viewpoints on natural healthcare have made her an in-demand and innovative expert in the natural health world.
Dr. Mary Riggin, produces and hosts Food is the First Medicine Talk Radio Show, and is a popular speaker.She has practices natural medicine in the Tampa Bay area; her passion and purpose is to help as many people as possible. Listen to her weekly on TanTalk 1340AM in Tampa Bay, or online anytime, anywhere at www.foodismedicine.org.
She is former Vice Chair of the Florida State Board of Acupuncture. She has been featured on various TV and radio shows and frequently teaches free classes at community and recreation centers throughout Pinellas County.
She is a published author and was featured in the book A Woman's Guide to Vitamins, Minerals and Alternative Healing, writes and publishes educational newsletters and brochures, and was elected to serve two consecutive terms as President of the Florida State Oriental Medical Association.
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